Trial Overview

The AIROPLANE Trial compares two different oxygen concentrations to help support a baby's breathing in the first few minutes after birth. We will assess whether either approach leads to babies having less need for later breathing support, oxygen treatment or less time in hospital.

The hospitals taking part in the AIROPLANE Trial will be allocated to use an initial oxygen concentration of either 21% or 30% for a period of approximately 12 months. After this time, the hospital will then change to using the alternative oxygen concentration for a similar period of time.

Safety measures have been built into the study design to ensure that every AIROPLANE baby always receives a safe level of oxygen. Should additional care be needed at any time this will always be provided immediately.

1,200 infants born between 32 and 35 weeks of pregnancy are being automatically enrolled into the AIROPLANE study.

Partners & Participating Centres